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Stressors in this category may include: Highly processed, sugar-heavy, or nutrient-poor diets Frequent blood sugar instability (alternating high-sugar meals and crashes) Food sensitivities, especially gluten intolerance , that cause chronic intestinal inflammation Excessive caffeine, which directly stimulates the adrenal glands and disrupts the natural cortisol rhythm Inadequate protein or essential fatty acid intake, limiting the raw materials for hormone production Environmental Stressors Environmental exposures are frequently underestimated as contributors to Adrenal Fatigue

In males, GPx5 is prominent in the epididymis, where it detoxifies peroxides to protect sperm during maturation and storage

doi: 10.1016/s0196-9781(03)00040-8

Both semaglutide and liraglutide are MHRA-approved and are supported by NICE technology appraisals TA875 for semaglutide and TA664 for liraglutide which set out specific eligibility criteria

While results are significant, regular treatments are required to maintain effects