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Sleepiness has been reported in about 6% to 13% of users, and fatigue in about 5% to 8% , depending on the study population and indication, according to this review on Lexapro tiredness and side effects

Thus, UPEC infection acts as an epi-mutagen reprogramming the urothelial epigenome, leading to urothelial-intrinsic remodelling and training of the innate response to subsequent infection

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