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Also, the prevalence of cannabis use among Colorado adolescents of all ages is greater than that of youth in the rest of the United States

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[50] [51] [52] Since most benzodiazepines are highly selective GABA A positive allosteric modulators, the anxiolytic effect mediated by increased GABAergic activity is stronger than alcohol, which binds to numerous other receptors and has poor selectivity as a GABAergic agent, and alcohol even acts as a negative allosteric modulator of NDMA receptors, which likely contributes to its impairing and euphoric effects, along with numerous other target receptors