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Blood 112 , 39393948 (2008)

Peer review Peer review information Nature Reviews Rheumatology thanks Caroline Jefferies, Amir Sharabi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

10.1093/nar/gkh036 97 HayrapetyanH.TranT.Tellez-CorralesE.MadirajuC

Asparagine endopeptidase cleaves -synuclein and mediates pathologic activities in Parkinsons disease

These products are cleaved into glutamine, cysteine, and glycine under the action of 5-oxoalaninase and Cys-Gly peptidase, respectively, and then added to new GSH synthesis [32, 37] (summarized in Fig