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Oxidative stress results when reactive forms of oxygen are produced faster than they can be safely neutralized by antioxidant mechanisms and/or from a decrease in antioxidant defense, which may lead to damage of biological macromolecules and disruption of normal metabolism and physiology [5]

It is also prescribed off-label for weight loss in people with obesity or overweight, as an adjunct to diet and exercise

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Consequently, research has shown evidence that helminth GSTs may have key roles in the establishment of infection and the development of anthelmintic resistance, as demonstrated in the parasitic flatworm Fasciola hepatica (Chemale et al ., Reference Chemale, Perally, LaCourse, Prescott, Jones, Ward, Meaney, Hoey, Brennan, Fairweather and Trudgett2010

This understanding provides a crucial foundation for exploring ferroptosis-driven mechanisms in osteoarthritis