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To further support the impact of CBS on replenishing GSH levels under cystine-restricted conditions, we expressed a codon-optimized CBS (CBS OPT ), which is resistant to the designed sgRNA (Fig

10.4292/wjgpt.v11.i5.93 [DOI] [PMC free article] [PubMed] [Google Scholar] Berra-Romani R., Avelino-Cruz J