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TNF is one of the most intensively studied pleiotropic pro-inflammatory cytokines and is primarily secreted by macrophages ( Figure 4 )

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Copper peptides (GHK-Cu) are naturally occurring peptide complexes found in human plasma

The STEP UP trial, a Phase 3b study published in The Lancet Diabetes & Endocrinology in 2025, evaluated a 7.2 mg weekly injection dose in over 1,400 adults with obesity (BMI of 30 or higher) and without diabetes

It is subsequently released at synapses in the brain, exerting short-term effects on postsynaptic excitability and longer-term effects on synaptic strength and neural plasticity