, 2023 ), while monomeric cytoplasmic p53 binds to G6PD and prevents the formation of an active dimer (Jiang et al
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This creates a vicious cycle, where impaired waste clearance contributes to ROS buildup, which in turn promotes neuroinflammation, alters sleep architecture, and leads to further fragmentation of sleep (Gu et al., 2022
10.1007/s10787-023-01214-z Inflammopharmacology
-hydroxybutyrate becomes a metabolic decoy that feeds normal tissues and lymphocytes while starving the tumor 383 , an idea first articulated by Sidney Weinhouse, the opponent of the metabolic theory of cancer 300,301 , and elaborated in modern ketogenic-diet studies 25