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Proc Natl Acad Sci U S A , 109 (38), 1510115108

However, recent investigations of alternative therapies for AD have sparked interest in compounds with disease-modifying capability, one such molecule, a natural polyphenol, is curcumin, which has anti-inflammatory and antioxidant properties (45)

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Furthermore, HRMS-based non-targeted analyses using MS/MS structural elucidation allowed to identify other relatively minor metabolites related to APAP-Cys such as S-(5-acetylamino-2-hydroxyphenyl)mercaptopyruvic acid (SAMP), an APAP metabolite potentially formed by the transamination reaction of APAP-cysteine (see Fig.1), previously observed in mouse ( 29 )

His kidney failure resulted from the high calcium levels in the blood, with calcium depositing in various parts of the kidney causing damage, Auguste explained