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This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia

It has shown promise in animal studies for promoting tissue healing, including in joints, by accelerating the repair of muscles, tendons, and ligaments, reducing inflammation, and potentially aiding in pain relief

Holzhey, P

Lipid-conjugated protamine peptides, developed as permeation enhancers, have enabled sublingual delivery of proteins with molecular weights from 22 to 150 kDa in mouse models, with effects comparable to subcutaneous injection

But rare does not mean irrelevant, especially when you are making decisions about your own body