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PLoS ONE 7 , e46803 (2012)

et al., 2019)

This mechanism may be attributed to the interference with copper ion transport leading to increased ROS levels, mitochondrial dysfunction and reduced ATP production, ultimately inhibiting Cu/Zn SOD1 activity (136)

10.2147/JIR.S542396 J Inflamm Res

To examine AP1 promoter activity following copper-induced upregulation of FOS , FOSB , JUN , and JUNB , a luciferase reporter assay was performed in HepG2 and HepG2 ATP7B-KO cells