Pulsatile versus tonic GH release biology: Studies comparing the downstream biological consequences of pulsatile GH release (produced by short-acting GHRH analogues and GHRPs) versus tonic GH elevation (produced by long-acting GHRH-DAC variants or continuous GH infusion) established that pulsatile GH patterns are more potent drivers of hepatic IGF-1 production and anabolic GH signalling than equivalent total GH doses delivered continuously providing the physiological rationale for preserving pulsatile GH release characteristics in GH secretagogue research designs
Haddad FG, Sasaki K, Issa GC, Garcia-Manero G, Ravandi F, Kadia T, Cortes J, Konopleva M, Pemmaraju N, Alvarado Y, Yilmaz M, Borthakur G , DiNardo C, Jain N, Daver N, Short NJ, Jabbour E, Kantarjian H
Authors also mention mutations of specific ion channels, such as TRESKpotassium channels encoded by gene KCNK18, which regulates the dorsal roots and trigeminal ganglia excitability
This is why both therapies are often discussed in longevity and performance circles, not as competitors, but as complementary tools
Storage is often the hidden culprit behind inconsistent results
