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, IL-6, IL-1, TNF-, and PGE2 )and serum lipopolysaccharides levels [216,217,218,219,220] and disrupting the intestinal environment, including reducing the diversity of intestinal microorganisms [216, 217] and fecal SCFAs [216, 217, 221], and regulating intestinal PH value [221] and oxidative stress through glycoxidation (NO, protein carbonyl (PCO), MPO and alkaline phosphatase (ALP)) [220, 221]

2025, doi: 10.1056/NEJMoa2502081

Biomedicine & Pharmacotherapy , 57(34), 145155

You will not know it has lost potency until your results stop

To minimize possible discomfort before your injection: Apply ice or an over-the-counter topical numbing cream to the injection site before cleaning it with the alcohol pad