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To further confirm this result, we treated tendon fibroblasts with BPC 157 at different concentrations (0, 0.1, 0.25 and 0.5 g/mL) for 24 h and the expression of growth hormone receptor was found to increase in a dose-dependent manner (Figure 1A,C)

The implication is that the combination may address a different portion of cardiovascular risk than either agent covers alone

ACS Omega 2 , 24992506, (2017)

Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis