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A subsequent analysis by the FDA also warned there were "significant analytical issues" with the study that made it difficult to compare the levels of harmful and potentially harmful compounds from heated tobacco to those from cigarettes

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However, due to the different nature of the IQOS Heets smoke (glycerol aerosol) compared to conventional cigarette smoke, oxidative reagents were also used (KMnO 4 , Fentons reagent, Joness reagent) to aid the retrieval of 210 Po from the washing flasks

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