Although advances in diagnostic technologies and therapeutic strategies have improved clinical outcomes, most patients with advanced LUAD eventually develop resistance to current treatments, resulting in disease progression
In other words, in addition to inhibiting the expression of p-STAT3, GHK-Cu likely targets other pathways that inhibit the expression of inflammatory factors
7.5 Critical discussion of translational challenges The translation of ferroptosis-targeting agents for AD faces multiple interconnected challenges, with BBB penetration, off-target effects, long-term safety, and perturbations of iron metabolism and immune function being the most prominent
1.1 What this review adds beyond existing literature Existing reviews typically treat phytochemical neuroprotection and BBB-targeted nanocarriers as separate topics
Besides its biological importance iodine salts are widely used in pharmaceuticals (Nobukuni, 2009) and antiseptic agents (Grzybowski et al., 2018), radiocontrast agents (Pasternak and Williamson, 2012), light bulbs (Bregnhj et al., 2019), solar cells (Sun et al., 2015), and LCD displays (Ma et al., 2011)