Supplementary Tables S5, S6)
Why combine CJC-1295 (No DAC) with Ipamorelin
Mechanism of action Sermorelin Sermorelin primarily functions as a GHRH stimulator, triggering the pituitary gland to secrete natural growth hormone
In fact, cultured adipocytes secrete more IGF-2 than IGF-1, and predominantly IGFBP-4
Additionally, the increase in hemichannel activation due to an increase in pro-inflammatory cytokines [e.g., tumor necrosis factor- (TNF-) and interleukin-1 (IL-1)] in primary cell cultures and mice results in an increase in the release of various ions (i.e., K + , Ca 2+ ) and gliotransmitters (i.e., ATP, glutamate) into the extracellular space, further disrupting homeostasis and possibly contributing to neuronal death (Retamal et al., 2007