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Iron overload induces ferroptosis by activating Piezo1, a pressure-sensitive calcium channel in chondrocytes, leading to subsequent calcium inflow, which could be exacerbated by conditional GPX4 knockout in cartilage

This is because, in years when government revenue fails to meet budget targets, capital expenditure is reduced to accommodate this shortfall

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Short-term outcomes of single-dose intra-articular injections were reported

This has been successful in diverting non stroke patients to the Emergency Department (ED) and avoid unnecessary hospital admissions