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During an asthma exacerbation and in the case of uncontrolled asthma, the airway environment becomes more acidic and oxidizing that leads to the release of NO from S-nitrosoglutathione (GSN), which leads to high levels of exhaled NO [2]

Regarding DILI, specific drugs (such as acetaminophen) are metabolized by CYP450 enzymes into reactive electrophiles

Side effects are more common at these higher doses