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Immunity (2015) 43(4):81729

In addition, the 51 molecule underwent in vitro evaluations for hyperuricemic effects with hyperuricemic rats, with allopurinol as the reference, and the conclusion of the study showed that compared to the model group, the 51 compound showed a 31% reduction in uric acid levels [70]

doi: 10.1002/pmic.200701097 366 ShaoJ.CuiY.ZhangM.WangT.WuD.WangC.et al

J Hypertens

These ROS oxidize PUFAs in cell membranes into lipid peroxides (PUFA-OOH), thereby destroying cell membrane structural stability, attacking cellular DNA and proteins, and causing ferroptosis