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433 Methylglyoxal, a reactive dicarbonyl by-product of glycolysis, induces post-translational modifications of the voltage-gated sodium channel Nav1.8, increasing the excitability of nociceptive neurons

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The rectal administration is also beneficial for patients who may have difficulty swallowing pills or for those who have gastrointestinal issues that could interfere with the absorption of oral medications

As the leading cause of schistosomiasis in the world, it is the most prevalent parasite in humans