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There are some data that acute COVID-19 infection is accompanied by signs of oxidative stress, including increased expression of ROS-response genes and glycolysis in peripheral blood mononuclear cells [72], increased MDA (TBARS assay), F-isoprostane, 8-hydroxy-2-deoxyguanosine, AOPP and nitrotyrosine levels, and lowered glutathione (GSH), -SH groups, selenium, zinc, TAC and vitamin D [49, 73,74,75,76,77,78,79]
, Liu Y
Through the complete inhibition of POIs and their downstream signaling cascades, covalent PROTACs are expected to benefit from the advantages including reduced systemic drug exposure due to their high potencies and improved selectivity
Furthermore, the inherent conformational flexibility in the S tail likely enables exposure of the extended motif for coatomer binding
Free radicals, or ROS, or oxidants are species occurring in all organelles or tissues, where they may act
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