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Under oxidative stress conditions, active cysteine residues of Keap1 undergo direct modifications, changing the structure of the active E3 ubiquitin ligase and leading to a breakdown in ubiquitination [23, 24]

Feng Q, Davey KG, A SDP, Ladd TR, Retnakaran A, Tomkins BL

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Importantly, JHU083 treatment reduces immunosuppressive cell populations in murine models, including monocyte and granulocyte-derived suppressive cells, regulatory T cells, and pro-tumor CD4 + Th17 cells [185]

Iron uptake, translocation, and regulation in higher plants