GLP-1 was shown in an in vitro experiment to protect - cells from methylglyoxal-induced apoptosis, by improving mitochondrial function and suppressing prolonged activation of AMP-dependent protein kinase (AMPK) ( Upon glucose stimulation, the pancreatic -cells release insulin into the circulation from secretory granules, where it is temporarily stored, along with another short peptide called amylin (islet amyloid polypeptide
10.7554/eLife.33033 68 SendakR
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Altogether, as proposed in the model in Figure 8 , we conclude that the protein-reactive QIs of AQ mainly trigger ER stress, eventually leading to apoptosis in HepG2 cells