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In vitro , Neuritin activated the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway in A 1-42 -stimulated HT22 neuronal cells, leading to increased NADK activity and NADPH expression, reduced MDA and ROS levels, and inhibition of neuronal ferroptosis

Mitochondrial Ca 2+ activates three dehydrogenases of the citric acid cycle resulting in increased ROS formation (Hatano et al

Mitochondrial ferrous iron can mediate the synthesis of heme and iron-sulfur (Fe-S)

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8. Supports Mood and Emotional Balance 8. Supports Mood and Emotional Balance Vitamin B12 plays a role in brain chemicals that affect mood