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When HK-2 cells were treated with MLN4924, the UBE2m overexpression-induced increase in neddylation and expression of NEDD4 was rescued, as was the decrease in PPAR expression induced by NEDD4 elevation (Fig

Yang KJ, Kim JH, Chang YK, Park CW, Kim SY, Hong YA (2019) Inhibition of xanthine oxidoreductase protects against contrast-induced renal tubular injury by activating adenosine monophosphate-activated protein kinase

Cp1B and Cp2B are pseudodipeptide-forming ATP-grasp enzymes The putative ATP-grasp enzyme Cp1B and the ANL-family enzyme Cp1D are responsible for the amide bond-forming steps to give 1 and analogs