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Excluded were those mothers who anticipated moving out of the area before study completion, who had twin or multiple pregnancies, who were treated for infertility, who tested positive for hepatitis B (hepatitis B surface antigen), HIV, or syphilis (Venereal Disease Research Laboratory test) infections, or who were taking daily vitamin supplements in addition to folic acid and iron

The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

Reduced Lipogenesis: Studies suggest it may help inhibit the production of new fat cells, thereby helping the body maintain a healthier body composition

Research shows NNMT inhibition dramatically improves how cells produce and utilize energy