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To investigate the role of proteasome-, lysosome-, or autophagosome-dependent pathways in the reduction of TGFBR1 protein induced by SIRT2, the inhibitory effects were evaluated using proteasome inhibitor MG132, lysosome inhibitor NH 4 Cl, and autophagosome inhibitor 3-MA

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This is the route where oral administration has the most biological plausibility because the peptide can act locally on gut epithelium without requiring high systemic absorption

Type 2 diabetes is also associated with an increased risk of uterine (endometrial) cancer and early menopause