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In addition, this combination not only inhibits inhibitor of nuclear factor kappa B (NF-B) phosphorylation, thereby reducing nuclear translocation of NF-B and suppressing downstream inflammatory cytokine expression (TNF- and ICAM-1 mRNA) within the NF-B signaling pathway but also mitigates phosphorylation of Janus Kinase 1 (JAK1) and signal transducer and activator of transcription 1 (STAT1), suppressing activation of the JAK1/STAT1 pathway to enhance inflammatory response inhibition post-cerebral ischemia

Cell cycle dependence on the mevalonate pathway: role of cholesterol and non-sterol isoprenoids

Sinomenine in cardio-cerebrovascular diseases: potential therapeutic effects and pharmacological evidences

The side-effect record is thinner than for FDA-approved drugs, so the picture below should be read as what has been reported , not what is known to be safe long-term

doi: 10.1007/s12016-021-08868-z