The biological plausibility of AOD9604s cartilage-regenerating effects is further supported by insights from conditions such as acromegaly, where excess GH leads to abnormally thick cartilage due to elevated local IGF-1 production
No Observed Effects On: Blood glucose or insulin sensitivity (no diabetogenic effects) IGF-1 levels (remained within normal ranges) Blood pressure or cardiovascular parameters Thyroid function Liver or kidney function markers Important: The absence of growth hormone-related side effects distinguishes AOD-9604 from full-length GH, which can cause fluid retention, joint pain, carpal tunnel syndrome, and insulin resistance
Research has demonstrated that the compound shows anti-proliferative activity in specific cancer cell lines, with HeLa cells showing concentration and time-dependent growth inhibition across a 0.1-500 M range while HEK-293 cells remain unaffected
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