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Keywords: Pernicious anemia, Vitamin B12, Neuropathy, Myelopathy, Parietal cells, Intrinsic factor, Autoimmune, Hyperpigmentation Background Vitamin B12 deficiency is a common global health concern that, if left untreated, can result in a range of hematological and neurological complications

Two practical consequences fall out of this mechanism, and both explain the shape of the protocol below

Biomarker monitoring, including fasting insulin, HOMA-IR, HbA1c, and body composition, is essential for assessing clinical response during a 12-week MOTS-c protocol

Research suggests that this is even more important for women who are pregnant or lactating (6)

[DOI] [PubMed] [Google Scholar] 195.Correll C.U., Schooler N.R