this change in redox status promotes a leukocyte mediated pro-inflammatory response that ultimately leads to the exacerbation of secondary damage (Hulsebosch et al., 2009)
The most studied SH with regards to inflammation, 2,5-dimethoxy-4-iodoamphetamine (DOI), has been shown to profoundly suppresses TNF- mediated inflammation in rodent tissues at picomolar concentrationsequating to a dose in humans at least two orders of magnitude below what is necessary to produce hallucinogenic effects [185, 193, 194]
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Int J Mol Sci 19 , (2018)