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However, observations suggest that in the brains of AD patients, increased angiogenesis may disrupt this negative feedback loop, leading to an imbalance between angiogenesis and vascular inhibition

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showed that transduction of Hnf1 and Foxa3 directly induced MEFs into hepatic stem cells which had the bipotential of differentiating into hepatocytes and cholangiocytes (Yu et al., 2013)