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In response to physical stimuli, these molecules can initiate signal transduction, modulate the intracellular ion concentration (e.g., calcium, sodium, and chloride), influence cellular tension, volume, and shape, and trigger transcriptional changes, thereby contributing to therapeutic resistance and mediating profound changes in cellular functions, including division, and migration (see sections below)

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5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule NNMT inhibitor studied in metabolic research