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The peptide maintains gastric mucosa integrity continuously, functioning as a natural protective agent against damage from various sources
Approval / sport note: Not FDA-approved in this research form
As a single agent in phase 2 dose-finding, cagrilintide produced dose-dependent weight loss of roughly 1011% at the highest dose over 26 weeks [4]
Moderate deficit works best: 300-500 calorie deficit below maintenance
This includes people with: Pernicious anaemia (autoimmune destruction of intrinsic factor-producing cells), typically requiring lifelong IM injections Crohn's disease or surgical resection affecting the terminal ileum Coeliac disease causing malabsorption (may improve with gluten-free diet) Chronic pancreatitis reducing enzyme availability needed for B12 release Vegans and strict vegetarians need reliable B12 sources through fortified foods or supplements, as plant-based diets contain negligible amounts of active B12
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