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KPV: Limited clinical and preclinical evidence Mechanistic NF-B data Small clinical trials in IBD (oral) and atopic dermatitis (topical/oral) No published subcutaneous human data for systemic effects

It uses bacteria like Pseudomonas denitrificans or Propionibacterium freudenreichii

Dietary tablet supplements of vitamin B12 and fortified foods are usually in the form of cyanocobalamin because it is a more cost-effective form of B12

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The conventional titration pattern ramps up to a 4 mg, 8 mg, or 12 mg maintenance dose after the 12-week introduction