Regular provider assessment of collagen markers, elasticity changes, and systemic tolerance guides dose modifications
J Gen Intern Med 27:15871593 Wood SL, Westbrook JA, Brown JE (2014) Omic-profiling in breast cancer metastasis to bone: implications for mechanisms, biomarkers and treatment
COX-2 selective NSAIDs (i.e., COX-2 inhibitors or coxibs) inhibit COX-2 more strongly than COX-1, resulting in less gastrointestinal side effects, but potential cardiovascular complications, most notably an increase in the risk of heart attack due to increased blood clotting propensity (see below) (Conaghan 2012)
Helbig K, Bleuel C, Krauss GJ, Nies DH: Glutathione and transition-metal homeostasis in Escherichia coli
Sources of depletion can include: Mitochondrial energy production (a normal and essential process, but creates harmful byproducts like ROS) Chronic infections, gut dysbiosis (including SIBO and Candida ), and ongoing inflammation Air pollution, heavy metals, and environmental toxins 17 Ultra-processed foods, sugar-sweetened beverages, and foods high in advanced glycation end products (heavily browned foods) 18 Pesticides and herbicides 19 Alcohol and smoking Psychological stress Even vigorous exercise (a healthy stressor that still creates oxidative byproducts) 20 Understanding this helps explain why simply eating well sometimes isnt enough, and why targeted nutritional strategies make a meaningful difference
