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Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice

Follow institutional protocols for reconstitution and aseptic handling

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Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)

Caspase-3 activation represents point of no return in apoptosis