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doi: 10.1186/s13018-025-05894-x 172 ShamjiMFSettonLAJarvisWSoSChenJJingLet al

Volume expansion (administration of one liter of NaCl 0.9% in one hour) resulted in a 40% reduction of ammonia concentration by significantly increasing ammonia excretion and reducing angiotensin II (ANG II) production

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The dose-limiting side effects that made first-generation secretagogues impractical for sustained use

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle