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Specifically, superoxide anion and hydroxyl radicals, also known as free radicals, are strongly oxidative due to the existence of one or more unpaired free electrons in their outer electron orbitals, therefore easily grabbing electrons from other substances and predisposing to free radical chain reactions, which causes immense damage to DNA, proteins, and lipids (31, 32)

10.1016/j.yjmcc.2014.06.010 28 GzM.GzP.SmolkaA

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The main concerns are quality control and lack of long-term human data