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[DOI] [PMC free article] [PubMed] [Google Scholar] 171.Rothstein J.D., Dykes-Hoberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., Kanai Y., Hediger M.A., Wang Y., Schielke J.P., et al

In cancer cells, high concentration of NO can damage various macromolecules such as nucleic acids and proteins and finally trigger apoptosis

they inhibit the activity of the pro-inflammatory enzyme 5-lipoxygenase and have demonstrated improvements in animal and human models of inflammatory diseases (including asthma, osteoarthritis, and Crohns disease) (Anonymous 2008)

Biogerontology 26 , 125 (2025)

Half patients with RA under anti-TNF- can successfully discontinue treatment after achieving remission [144, 145], while this is less feasible for patients with established RA [145]