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A small proportion of people experience a temporary rough-texture phase sometimes called the copper peptide uglies, thought to be driven by MMP activity briefly outpacing new collagen synthesis when starting at too high a frequency

Ishizawa J, Nakamaru K, Seki T, Tazaki K, Kojima K, Chachad D, DiNardo CD, Pierce S, patel KP, Tse A, Davis RE, Rao A, Andreeff M