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Recent human studies have highlighted presence of bioenergetic maladaptation in brains in aging and neurodegenerative disorders, including PD [4, 5]

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These data, along with expedited communication of bioinformatic predictions and epitope mapping 15,16,17,18 , has provided crucial knowledge enabling vaccine design beyond development of live-attenuated and inactivated vaccines 19,20,21,22,23

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