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G-protein coupled receptors in metabolic reprogramming and cancer

Acetyl-L-carnitine activates the peroxisome proliferator-activated receptor- coactivators PGC-1/PGC-1-dependent signaling cascade of mitochondrial biogenesis and decreases the oxidized peroxiredoxins content in old rat liver

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Accordingly, qRT-PCR and western blot (WB) analyses revealed increased expression levels of the key lipogenic enzymes ATP Citrate Lyase (ACLY) in 4T1 cells and Fatty Acid Synthase (FASN) in both 4T07 and 4T1 cells when compared to 67NR cells (Figs

Under these conditions, the reaction rate depends on both the substrate binding affinity (related to K M ) and the conversion rate after binding (related to k cat ), making both k cat and K M substantial parameters 92