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1 Dosage volume is consistent with published protocols 1,2 The FDA approval of HepaGam B for the prevention of hepatitis B recurrence following liver transplantation in HBsAg-positive patients is based on the dose of 20,000 IU used in the pivotal clinical trial Total dose should be calculated based on the measured potency stamped on each 5 mL vial label: this provides a dose that is consistent with published protocols HepaGam B Intravenous Infusion Rate HepaGam B dose adjustments may be required in patients who fail to reach anti-HBs levels of 500 International Units per liter within the first week post-liver transplantation

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