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Of note, gastrointestinal (GI) disorders such as gallstones and gastroesophageal reflux disease (GERD) have been identified as mostly non-metabolic complications of obesity and are also listed among possible adverse events (AE) of incretin-based AOM
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Importantly, a mutation in PNPLA3 (rs738409), I148M, is the single greatest genetic risk factor for the development of FLD (64-67), however its precise function in neutral lipid metabolism is controversial (68, 69)
Regarding molecular mechanism of ROS against biomolecules, free species like NO , NO 2 , H 2 O 2 , and ONOO - can cross lipid membranes and carry signals across organelles, while other types of ROS have limited half-life or physical properties that contribute to damaging of other biological molecules
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