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Microbiota, gut hormones, and metabolic processes EECs are distributed along the length of the intestinal epithelium and serve as the major cell type for nutrient sensing and trigger subsequent signaling through the release of gut hormones (Fig

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Moreover, isoorientin inhibited the growth of some inflammation-causing pathogenic bacterial genera such as Alistipes , Helicobacter and Oscillibacter (Reference Yuan, Li and He60)

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(3) the more effective combination partner, phenformin, has been linked to increased lactic acidosis in patients 80 , which is to be avoided in patients with CRC