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This high metabolic rate leads to increased production of reactive oxygen species (ROS) as byproducts of cellular respiration.Presence of Redox-Active Metals: The brain contains transition metals such as iron and copper, which can catalyze the formation of highly reactive hydroxyl radicals through the Fenton reaction.Limited Regenerative Capacity: Unlike some other tissues, neurons have limited regenerative capacity

Some studies report higher glutathione levels and antioxidant capacity in postmenopausal women versus premenopausal women

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As antioxidants, phenolic acids typically activate the Nrf2 pathway in normal cells, enhancing cytoprotective antioxidant enzymes

Genhong Yao, Nanjing Drum Tower Hospital, China Updates Copyright 2020 Spihlman, Gadi, Wu and Moulton