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Liver fibrosis is a key marker of MASLD/MASH progression, initiated by elevated hepatocyte expression of pro-fibrotic TFs such as Sox9 and secreted factors such as Spp1 (osteopontin) and Tgfb1 (TGF-1)

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Wang Y, Quesada AE, Zuo Z, Medeiros LJ, Yin CC, Li S, Xu J, Borthakur G , Li Y, Yang C, Abaza Y, Gao J, Lu X, You MJ, Zhang Y, Lin P