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There is substantial evidence that the expression of SOCS3 protein increases with aging in several cells/tissues, such as rat myocardium [162], hypothalamus [163], and human blood mononuclear cells [164] as well as human sarcopenic skeletal muscles [165] and the brains of Alzheimers patients [166]

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Ah Mew N, Caldovic L (2011) N -acetylglutamate synthase deficiency: an insight into the genetics, epidemiology, pathophysiology, and treatment

[DOI] [PubMed] [Google Scholar] 42.Scannevin R.H., Chollate S., Jung M.Y., Shackett M., Patel H., Bista P., Zeng W., Ryan S., Yamamoto M., Lukashev M., et al

There are many glutathione molecules conjugated to each agarose bead, so multiple GST-fusion proteins can bind to the same bead (Figure 3)